Table 3.
BPA glucuronidation activities and UGT genotypes and determined for 15 breast tissue samples. Samples are ordered in the table from highest to lowest BPA glucuronidation activity.
| BPA glucuronidation rate | Polymorphism genotype
|
|||
|---|---|---|---|---|
| Sample ID | (fmoles/min/mg protein) | UGT1A1*28 | UGT1A9*22 | UGT2B15*2 |
| 165 | 56 | *1/*1 | *1/*22 | *1/*2 |
| 47 | 36 | *1/*1 | *1/*22 | *1/*2 |
| 160 | 23 | *1/*1 | *22/*22 | *1/*1 |
| 171 | 22 | *1/*1 | *22/*22 | *1/*1 |
| 156 | 21 | *1/*1 | *1/*22 | *1/*2 |
| 168 | 21 | *1/*1 | *1/*22 | *1/*1 |
| 164 | 16 | *1/*1 | ? | *1/*1 |
| 172 | 5.4 | *1/*1 | *1/*22 | *2/*2 |
| 159 | 4.5 | *1/*1 | *1/*22 | *2/*2 |
| 167 | 3.3 | *1/*28 | *1/*1 | *2/*2 |
| 20 | 3.3 | *1/*28 | *1/*22 | *2/*2 |
| 169 | 2.5 | *1/*1 | *1/*1 | *2/*2 |
| 158 | 0.2 | *1/*28 | *22/*22 | *1/*2 |
| 29 | 0a | *1/*28 | *1/*1 | *1/*2 |
| 17 | 0a | *1/*28 | *1/*22 | *1/*1 |
a
Less than the lower limit of quantitation (LLOQ, 0.2 fmoles/min/mg protein)
?
unable to determine genotype