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From top left: Underlying true dose–toxicity models for scenarios A–F with the corresponding MTD specified for a 30% DLT rate. Scenarios A and B models are PO models, scenarios C and D models violate the PO assumption, and scenarios E and F models are CR models.
MTD: DLT: dose-limiting toxicity; CR: continuation ratio; PO: proportional odds; MTD: maximum tolerated dose.
