Table 1.

50–50 weighting scheme details: pseudodata represent one cohort (three patients), in a 3/30 cohort size/total sample size scenario

Number of pseudodata points	Weight per pseudodata point	Observed patients	Weight per patient	Sum of weights	Percentage of weights from pseudodata	Percentage of weights from observed patients
400	0.0075	3	1	6	50.00	50.00
400	0.0075	6	1	9	33.33	66.67
400	0.0075	9	1	12	25.00	75.00
400	0.0075	12	1	15	20.00	80.00
400	0.0075	15	1	18	16.67	83.33
400	0.0075	18	1	21	14.29	85.71
400	0.0075	21	1	24	12.50	87.50
400	0.0075	24	1	27	11.11	88.89
400	0.0075	27	1	30	10.00	90.00
400	0.0075	30	1	33	9.09	90.91