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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Bioorg Med Chem Lett. 2016 May 19;26(14):3282–3286. doi: 10.1016/j.bmcl.2016.05.054

Scheme 1.

Scheme 1

Synthesis of 7-(dialkylamino)-2-oxo-2H-chromene-3-carboxylic acid. (a) alkyl bromide, K2CO3, DMSO or EtOH, 80 °C, 12 h; (b) POCl3, DMF, 0 °C to 80 °C, 2–4 h; (c) (i) diethyl malonate, piperidine, CH3COOH, EtOH, 80 °C, 8–12 h (ii) 10% NaOH, 100 °C, 2 h (iii) 3 M HCl, pH 7.0; reported yields are from the reaction of 3 to 4.