Skip to main content
. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Bioorg Med Chem Lett. 2016 May 19;26(14):3282–3286. doi: 10.1016/j.bmcl.2016.05.054

Table 3.

In vitro Caco-2 monolayer permeability (pH 6.5/7.4, at 10 μM)

A – B permeability (Caco-2, pH 6.5/7.4)
Compounds Permeability (10−6 cm/s)
Mean* 		Percent recovery (%)
Mean*
4a 32 34
Propranolol 40.9 67
Labetalol 8.5 66
Ranitidine ND** ND**
Colchicine 0.3 75
B – A permeability (Caco-2, pH 6.5/7.4)
4a 6.4 55
Propranolol 41.5 80
Labetalol 36.5 72
Ranitidine 3.7 85
Colchicine 15.3 81
*

Mean of two experiments.

**

ND = not determined.