Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Intrinsic clearance in mice liver microsomes (0.1 μM)
| Intrinsic clearance (liver microsomes, mouse)
| ||||
|---|---|---|---|---|
| Compounds | Half-life*
|
Clint | ||
| Trial 1 | Trial 2 | Mean | ||
| 4a | 90.6 | 73.5 | >60 | <115.5 |
| Propranolol | 9.1 | 9.5 | 9 | 744.5 |
| Imipramine | 15.7 | 15.4 | 16 | 446.2 |
| Verapamil | 17.6 | 17.5 | 18 | 394.6 |
| Terfenadine | 7.5 | 6.1 | 7 | 1027.4 |
Half-life is reported in minutes, mean value of two experiments.
