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ddPCR quantification of pSMN mRNA in LCM-collected motor neurons in the dorsal and ventral horn, compared to pSMN levels in blood at the last time point. Ventral horn motor neurons showed a significant decrease in pSMN in the shRNA-knockdown group (71.7%) as compared to the non-injected control group. The dorsal horn and blood do not show any decrease in pSMN. (***p≤0.001, t-test, error bars = sem)
