Table 1.
Dose recovered | 0.1 μmol/kg (Mouse, oral) | 0.1 μmol/kg (Rat, oral) | 10 μmol/kg (Rat, oral) | 0.1 μmol/kg (Rat, IV) | |
---|---|---|---|---|---|
Feces | % | 92 ± 7 | 98 ± 8 | 98 ± 1 | 77 ± 4 |
Urine | % | 3 ± 2 | 0.3 ± 0.03 | 0.3 ± 0.04 | 1.3 ± 0.2 |
Adipose | % | 0.1 ± 0.03 | 0.01 ± 0.01 | 0.03 ± 0.01 | 2 ± 0.4 |
(pmol-eq/g) | (2 ± 1) | (0.04 ± 0.1) | (28 ± 10) | (15 ± 3) | |
Adrenal | % | 0.01 ± 0.004 | 0.002 ± 0.002 | 0.004 ± 0.002 | 1 ± 0.1 |
(pmol-eq/g) | (18 ± 6) | (7 ± 5) | (1314 ± 451) | (2207 ± 1246) | |
Blood | % | 0.02 ± 0.01 | 0.4 ± 0.4 | 0.1 ± 0.1 | 1 ± 0.3 |
(pmol-eq/g) | (0.02 ± 0.01) | (0.2 ± 0.2) | (3 ± 5) | (0.4 ± 0.1) | |
Brain | % | 0.01 ± 0.01 | 0.0002 ± 0.0004 | 0.001 ± 0.001 | 0.04 ± 0.02 |
(pmol-eq/g) | (1 ± 1) | (0.02 ± 0.05) | (13 ± 14) | (5 ± 2) | |
Kidney | % | 0.01 ± 0.01 | 0.001 ± 0.001 | 0.002 ± 0.002 | 0.2 ± 0.03 |
(pmol-eq/g) | (1 ± 1) | (0.1 ± 0.1) | (21 ± 32) | (22 ± 4) | |
Liver | % | 0.3 ± 0.1 | 0.2 ± 0.2 | 0.4 ± 0.1 | 7 ± 1 |
(pmol-eq/g) | (11 ± 0.4) | (4 ± 5) | (873 ± 328) | (144 ± 21) | |
Lung | % | 0.01 ± 0.01 | 0.001 ± 0.001 | 0.002 ± 0.0004 | 0.1 ± 0.02 |
(pmol-eq/g) | (2 ± 2) | (0.1 ± 0.2) | (29 ± 4) | (20 ± 5) | |
Muscle | % | 0.1 ± 0.1 | 0.1 ± 0.2 | 0.1 ± 0.1 | 5 ± 1 |
(pmol-eq/g) | (0.4 ± 0.3) | (0.2 ± 0.4) | (10 ± 14) | (10 ± 2) | |
Skin | % | 0.001 ± 0.002 | 0.01 ± 0.01 | 0.04 ± 0.02 | 3 ± 0.4 |
(pmol-eq/g) | (0.01 ± 0.02) | (0.04 ± 0.1) | (24 ± 13) | (17 ± 3) |