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. 2017 Jun 26;127(8):2904–2915. doi: 10.1172/JCI75005

Figure 2. CCR2 and CX3CR1 are required for enrichment of M2 macrophages in the regressing plaque.

Figure 2

Quantification of immunohistochemical staining for (A) markers of M2 macrophages MR and ARG1 and (B) the macrophage marker CD68 and an M1 macrophage marker MCP-1, in aortic arch plaques from Apoe–/– mice on a 16-week WD (BL; n = 10) or 5 days after transplantation into Apoe–/– (Progr; n = 10), WT (Regr; n = 10), or chemokine receptor–deficient recipient mice (Ccr2–/–, Cx3cr1–/– or Ccr5–/–; n = 8). *P < 0.01 compared with Apoe–/– progression group using 1-way ANOVA with Dunnett’s multiple comparisons testing. (C) Representative images of aortic plaques stained for MCP-1, CD206 (MR), and ARG1, imaged at ×40 magnification.