Figure 3. A 6-hour exposure to VOR ex vivo increased HIV gag RNA in resting CD4⁺ T cells isolated from aviremic donors.

Pools of 24 million resting CD4⁺ T cells isolated from aviremic donors were exposed to 335 nM VOR or mitogen (PHA and 60 U/ml IL-2) for 6 hours, and rca-HIV RNA levels were measured. Data represent the mean ± SD. P < 0.05 to P < 0.0001 (Mann-Whitney U test) for all comparisons between untreated cells and ex vivo VOR–treated cells.