Fig. 4.
Blockage of the ATP effect on NLC by P2x receptor antagonists. a–c Applications of PPADS, suramin, and DIDS eliminate the effect of ATP on OHC electromotility-associated NLC. The block is reversible. The horizontal bars represent ATP and blocker applications. d Elimination of the ATP effect on the Vpk of NLC by P2 receptor antagonists. The Vpk shift for the application of 36 μM ATP under the treatments of P2 receptor antagonists was normalized to the response at the pretreatment in the same cell and then averaged. Error bars represent SE. Asterisks indicate that there is a significant difference in statistical analysis (P<0.001, paired t test)