Table 3. Summary of measures of association between herpes zoster (type unspecified)* and cardiac events in reviewed studies.
| Outcome | Reference | Follow Up Period After HZ |
n Events / n with HZ |
Adjustment Variables | Measure of Association** | Adjusted Association Size (95% CI) |
|---|---|---|---|---|---|---|
| Cardiac Events | ||||||
| Myocardial Infarction | Minassian et al | 1 week | 213** | AGE | IR | 1.68 (1.47 to 1.92) |
| Yawn et al. | 3 months | 24 / 4,405 | AGE, CHD | OR | 1.68 (1.03 to 2.75) | |
| Yawn et al. | 6 months | 35 / NR | AGE, CHD, DM | OR | 1.44 (0.97 to 2.15) | |
| Yawn et al. | 1 year | 61 / NR | AGE, SEX, CHD, DM, DEP | OR | 1.33 (0.99 to 1.80) | |
| Yawn et al. | 3 year | 154 / 4,102 | AGE, SEX, HTN, CHD, DM | OR | 1.17 (0.97 to 1.41) | |
| Breuer et al. | 24 years | 2,762 / 106,601 | AGE, SEX, BMI, SMK, DYSLIP, HTN, DM, CHD, AF, PVD, CRTD, VALV | HR | 1.10 (1.05 to 1.16) | |
| Acute Coronary Syndromes | Wang et al. | 3 months | 58 / 57,958 | AGE, SEX, URBN, INC, OCPTN, CLIN, HTN, DM, HYPLIP, CVD, COPD, RENAL, CNCR, MEDS | HR | 1.20 (0.89 to 1.62) |
| Wang et al. | 1 year | 193 / 57,958 | AGE, SEX, URBN, INC, OCPTN, CLIN, HTN, DM, HYPLIP, CVD, COPD, RENAL, CNCR, MEDS | HR | 1.14 (0.94 to 1.39) | |
| Wang et al. | 12 years | 860 / 57,958 | AGE, SEX, URBN, INC, OCPTN, CLIN, HTN, DM, HYPLIP, CVD, COPD, RENAL, CNCR, MEDS | HR | 1.15 (1.07 to 1.24) | |
| Coronary Artery Disease | Wu et al. | 2 years | 388 / 19,483 | AGE, SEX, DM, HTN, HYPLIP | HR | 1.14 (1.02 to 1.28) |
| Wu et al. | 10 years | 1,057 / 19,483 | AGE, SEX, DM, HTN, HYPLIP | HR | 1.11 (1.04 to 1.19) | |
*Cases of herpes zoster ophthalmicus were included in all cases of the exposures,
** Comparison of patients with herpes zoster to those without (referent group)
Abbreviations (Alphabetically): AF: atrial fibrillation, ARTHM: arrhythmia, BMI: body mass index, CLIN: frequency of clinical visits, CNCR: cancer, CRTD: carotid disease, CHD: coronary heart disease, COPD: chronic obstructive pulmonary disease, CVD: cerebral vascular disease, DEP: depression, DM: diabetes mellitus, GEO: geographical region, HF: heart failure: HR: hazard ratio, HYPLIP: hyperlipidemia, HTN: hypertension, HZ: Herpes Zoster, INC: income, IR: incidence ratio, IRR: incidence rate ratio, MEDS: medication use, NR: not reported, OCC: occupation, PVD: peripheral vascular disease, RENAL: renal disease, SCCS: self-controlled case series, SN: season, SMK: smoking statin, URBN: urbanization level of patient’s area of residence, VALV: valvular disease