Table 4. Summary of measures of association between herpes zoster ophthalmicus and cardiovascular events in reviewed studies.

Outcome	Reference	Follow Up Period After HZO	n Events / n with HZ	Adjustment Variables	Measure of Association*	Adjusted Association Size (95% CI)
Cerebrovascular Events
Stroke (Non-Specified)	Schink et al.	3 months	31*	AGE	IRR	1.59 (1.10 to 2.32)
	Langan et al.	4 months	22*	AGE	IR	3.38 (2.18 to 5.24)
	Kang et al.	1 year	7 / 120	AGE, SEX, HTN, DM, CHD, HYPLYP, RENAL, AF, HF, VALV, CRTD, INC, URBN, GEO	HR	4.28 (2.01 to 9.03)
	Lin et al.	1 year	53 / 658	AGE, SEX, HTN, HYPLIP, DM, CHD, RHD, MEDS	HR	4.52 (2.45 to 8.33)
	Breuer et al.	24 years	68 / 1,710	AGE, SEX, BMI, SMK, DYSLIP, HTN, DM, CHD, AF, PVD, CRTD, VALV	HR	1.03 (0.77 to 1.39)
Ischemic Stroke	Minassian et al.	1 week	93*	AGE	IR	2.73 (2.22 to 3.35)
	Minassian et al.	3 months	326*	AGE	IR	1.29 (1.15 to 1.44)
	Schink et al.	3 months	27*	AGE	IRR	1.57 (1.05 to 2.35)
Hemorrhagic Stroke	Schink et al.	3 months	4*	AGE	IRR	1.82 (0.62 to 5.37)
Coronary Events
Myocardial Infarction	Minassian et al.	1 week	43 (SCCS)	AGE	IR	2.06 (1.52 to 2.79)

* Comparison of patients with herpes zoster to those without (referent group)

Abbreviations (Alphabetically): AF: atrial fibrillation, BMI: body mass index, CLIN: frequency of clinical visits, CNCR: cancer, CRTD: carotid disease, CHD: coronary heart disease, COPD: chronic obstructive pulmonary disease, CVD: cerebral vascular disease, DEP: depression, DM: diabetes mellitus, GEO: geographical region, HF: heart failure: HR: hazard ratio, HYPLIP: hyperlipidemia, HTN: hypertension, HZ: Herpes Zoster, INC: income, IR: incidence ratio, IRR: incidence rate ratio, MEDS: medication use, NR: not reported, OCC: occupation, PVD: peripheral vascular disease, RENAL: renal disease, SSN: season, SMK: smoking statin, URBN: urbanization level of patient’s area of residence, VALV: valvular disease