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. 2017 Jul 27;12(7):e0181146. doi: 10.1371/journal.pone.0181146

Table 2. Characteristics of included articles.

Authors, year Type of review Database searched Primary studies
Airway assessed Included studies Participants Patients Interventions
(Number of studies)
Outcome measures Maximum follow-up period Range
Studies with mandibular advancement /Total number of primary studies Type Total number
(Range)
M/F Age
(Range of mean) years old
Airway parameters
(Measurement methods)
Respiratory parameters
Alsufyani et al, 2013[9] SR Medline, EBM#, Scopus OP;
partial NP
4/7 1 CS;
3 CR
7
(1–4)
4/3 Mean: 43 SDB/ OSAS MMA(4) Total volume,
MCS area,
linear,
total pressure drop,
airway resistance
(CBCT)
AHI,
Sleep Q Epworth sleepiness scale
7 weeks-6 months
(NR: 1 study)
Caples et al, 2010[10] MA (MEDLINE, EMBASE, Current Contents, Cochrane CENTRAL through Ovid) NR 9/70 9 O 234
(NR)
9:1 (ratio) 43.9
(41–48)
OSA MMA (9) NR AHI NR
Christovam et al, 2016[11] MA Cochrane library, Medline, Scopus, VHL, Web of Science, Open-Grey. UA 11/27 9 R;
2 P
252
(9–102)
102/112
(NR:2 studies)
22–44.6 NR MMA (9);
MdA (1);
MMA/MdA (1)
Cross-sectional area and volume
(10 CBCT/CT; 1 MRI)
NR 5 weeks-1 year
(NR: 1 study)
Elshauget al, 2007[12] MA Medline NR 4/18 4 CS 38
(5–15)
NR NR OSA MMA (3)
MMA/MdA (1)
NR AHI NR
Hsieh and Liao, 2013[14] SR PubMed PAS 15/15 15 CS
(2P, 13R)
376
(11–50)
219/
157
33–51 OSA MMA (15) Linear (posterior airway space, airway length);
Vertical hyoid position
(CT and ceph)
AHI,
RDI,
LSAT
6 weeks– 21.8 months
Holty and Guilleminault, 2010[13] MA Medline PAS 59/59 CS;
CR
957
(1–175)
836/
121
Mean: 44.4±9.4 OSA MMA (59) PAS
(Ceph)
AHI,
SpO2 nadir
3–7.7 months
Knudsen et al, 2015[15] MA PubMed, Cochrane PAS 4/4 NR 115
(17–40)
NR NR OSA MMA (4) NR AHI, LSAT NR
Mattos et al, 2011[16] MA VHL, Scirus, Ovid, SIGLE. OP 5 β/22 4 R
1P
135
(12–58)
40/83
(NR:1 study)
21–36.3
(NR:1 study)
NR MdA(3);
MMA(2)
Linear
(Ceph)
NR 6 weeks– 12 years
Rosario et al, 2016[3] MA PubMed,
Scopus,
Science Direct,
SciELO
UA 7 α/7 CCT 103
(10–25)
47/46
(NR:1 study)
22–42.75
(NR:1 study)
OSA (4);
Others (3)
MMA (7) Volume
(CT)
AHI 2–49 months
(NR: 1 study)
Pirklbauer et al, 2011[17] SR PubMed NR 28/28 1 RCT
5 Co
22 CS/CR
917
(3–175)
561/87
(NR: 269 patients)
41.0–50.3 OSA MMA (28) NR AHI,
RDI
2–12 months
(NR: 1 study)
Zaghi et al, 2016[18] δMA Cochrane library, Scopus, Web of Science, Medline PAS 45/45 1 RCT
(NR: 44 studies)
518
(1–35)
282/57
(NR: 179 patients)
Mean: 45.3 ±10 OSA
MMA (45)
Linear
(Ceph)
AHI,
RDI
2–6 months

# EBM = All evidence-based medicine reviews (EBM), including Cochrane Database

β 2 articles[5, 37] have included both mandibular advancement and setback surgeries.

α Only 6 studies included in the meta-analysis (One study did not report absolute value for average on difference)

δ Meta-analysis was only performed on respiratory parameters only

Abbreviations: SR = systematic review; MA = meta-analysis; NP = nasopharyngeal, OP = oropharyngeal, HP = hypopharyngeal, UA = upper airways, PAS = Posterior airway space; R = Retrospective study; O = Observational, P = Prospective study; CCT = Case controlled trials; Co = Cohort study, CS = Case series; CR = Case report; SDB = Sleep disordered breathing; OSAS = obstructive sleep apnea syndrome; MdA = Mandibular advancement, MMA = Maxillomandibular advancement; MCS area = Minimum cross-sectional area; Ceph = Cephalometric; CT = Computed tomography; CBCT = Cone-beam computed tomography; MRI = magnetic resonance imaging; AHI = Apnea-hypopnea index; RDI = respiratory disturbance index; SpO2nadir = lowest oxyhemoglobin saturation measured during sleep; LSAT = lowest oxygen saturation, NR = not reported