Table 3. Percent change in antibiotic prescription rates by Canadian physicians for treating outpatient acute rhinosinusitis by antibiotic class, 2007–2013.
| Antibiotic Class | Prescription rate per 10,000 inhabitants | Percent change in antibiotic prescription rate | |
|---|---|---|---|
| 2007 | 2013 | ||
| Tetracyclines (Doxycycline and tetracycline) | 3.1 | 8.0 | 158.1% |
| Penicillins with extended spectrum (amoxicillin) | 115.5 | 153.5 | 32.9% |
| Combinations of penicillins, incl. β-lactamase inhibitors (amoxicillin-clavulanic acid) | 31.0 | 34.9 | 12.6% |
| Cephalosporins (overall) | 62.1 | 35.9 | -42.2% |
| First-generation cephalosporins (cefadroxil and cephalexin) | 16.6 | 1.7 | -89.8% |
| Second-generation cephalosporins | 39.9 | 29.8 | -25.3% |
| Cefprozil | 18.6 | 3.8 | -79.6% |
| Cefuroxime | 3.3 | 4.8 | 45.5% |
| Cefuroxime axetil | 20.8 | 19.3 | -7.2% |
| Third-generation cephalosporins (cefixime) | 1.5 | 6.9 | 360.0% |
| Combinations of sulfonamides and trimethoprim, incl. derivatives (Sulfamethoxazole and sulfadiazine) | 12.3 | 1.7 | -86.2% |
| Macrolides | 203.5 | 105.4 | -48.2% |
| Azithromycin | 48.3 | 29.0 | -40.0% |
| Clarithromycin | 147.3 | 76.4 | -48.1% |
| Fluoroquinolones | 87.1 | 46.8 | -46.3% |
| Ciprofloxacin | 8.0 | 1.6 | -80.0% |
| Levofloxacin | 24.9 | 12.8 | -48.6% |
| Moxifloxacin | 54.2 | 32.4 | -40.2% |
| All Drugs | 517.0 | 387.6 | -25.0% |