Table 1. Clinical characteristics of the population.
| Cases (n) | %/SD | Controls (n) | %/SD | p-value6 | |
|---|---|---|---|---|---|
| Total number | 794 | 49% | 8281 | 51% | |
| VTE | 794 | ||||
| DVT | 600 | 75.5% | |||
| PE | 194 | 24.5% | |||
| Age (mean) | 32 [17–49] + | SD: ± 9.6+ | 31.5 [18–51] + | SD: ± 9.0+ | 0.1 |
| BMI (mean) | 24 [18–37] + | SD: ± 5.2+ | 23 [17.5–33.5] + | SD: ± 4.2+ | 6.6E-06 |
| Family history of VTE | 222 | 28% | 19(317)2 | 15(38)2% | 1.7E-03 |
| Smoking | 260 | 33% | 206 | 25% | 4.7E-04 |
| Cancer | 6 | 0.7% | 23 | 0.2% | 0.4 |
| Autoimmune disease | 8 | 1% | 43 | 0.7% | 0.65 |
| Thrombophilia factors: | |||||
| Protein C | 20 | 2.5% | 73 | 1.6% | 0.1 |
| Protein S | 10 | 1.2% | 123 | 0% | 0.15 |
| Antithrombin | 6 | 0.8% | 21 | 0.5% | 0.4 |
| F5-Leiden | 132 | 16.5% | 10(98)4 | 3(13)4% | 3.3E-09 |
| Prothrombin (F2) | 80 | 10% | 3(64)5 | 2(8)4% | 3.8E-03 |
+ 95%CI (in brackets) and Standard deviation (SD) are indicated for these parameters
1 The total number of controls differs depending on the variable as indicated in 2 and 3.
2 This variable was set as missing or was missing for 700 control women as indicated in M&M and the total number of controls used here is 128 controls. The number indicated in brackets is the original number before correction for bias.
3 This parameter is missing for 305 control women.
4 This variable was set as missing for 523 control women as indicated in M&M and the total number of controls used here is 305 controls. The number indicated in brackets is the original number before correction for bias.
5 This variable was set as missing for 697 control women as indicated in M&M and the total number of controls used here is 131 controls. The number indicated in brackets is the original number before correction for bias.
6 p-values calculated using Wilcoxon rank-sum test to compare cases to controls.