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. 2017 Jul 27;12(7):e0182057. doi: 10.1371/journal.pone.0182057

Fig 5. Anti-inflammatory effects of GW-A2 in vivo.

Fig 5

(A) The levels of IL-1β, IL-6 and TNF-α in the serum collected 4 h after LPS injection were measured by ELISA. (B) The levels of IL-1β, IL-6 and TNF-α in the peritoneal lavage collected 24 h after LPS injection were measured by ELISA. (C) The levels of iNOS, COX-2 and NLRP3 in lung and liver were assayed by Western blotting. (D) The H&E staining of lung and liver tissue sections from the indicated group. The infiltration of PMN was indicated by red arrows. Original magnification x 400. (E) PMN infiltration index of lung and liver tissue sections. * and ** indicate significant differences, representing p < 0.05 and p < 0.01, respectively compared to control mice. # and ## indicate significant differences, representing p < 0.05 and p < 0.01, respectively compared to LPS-injected mice.