Table 4. Associations of APC mutation and MYC copy number gains with estimates of immune cell levels.
Variant | Signature | Breast | Breast (LumB) | Colon | Head and Neck | Kidney Papillary Cell | Stomach |
---|---|---|---|---|---|---|---|
APC mutant | MFm2 | -0.75 (5) | |||||
APC mutant | Mono | -0.77 (5.2) | |||||
APC mutant | NK | 5.09 (9.4) | |||||
APC mutant | NKCD8 | 4.81 (7.2) | |||||
MYC gain | Bcell | -0.27 (1.9) | -0.22 (1.9) | ||||
MYC gain | MFm2 | 0.2 (2.2) | |||||
MYC gain | Mono | 0.19 (1.7) | |||||
MYC gain | TregCD8 | 0.1 (1.5) |
Values are reported as Effect Size with associated P values in parenthesis (-log10 P). The units of effect size are change in signature score (units of standard deviation) for mutant versus wild type in the case of mutations. For copy number changes the effect size is in S.D. units per change in GISTIC2 score.