Table 5. Association of RAS/RAF oncogene family member mutations with estimates of immune cell types across TCGA.
| Variant | Signature | Bladder | Colon | Testicular | Thyroid |
|---|---|---|---|---|---|
| BRAF mutant | MFm2 | 0.4 (2.7) | |||
| BRAF mutant | Mono | 0.45 (3.9) | |||
| BRAF mutant | NK | 0.58 (1.4) | |||
| BRAF mutant | NKCD8 | -0.38 (3.9) | |||
| BRAF mutant | Tcell | 0.48 (6) | |||
| BRAF mutant | Treg | 0.66 (14.9) | |||
| BRAF mutant | TregCD8 | 0.43 (5.9) | |||
| BRAF V600E | MFm2 | 0.45 (3.1) | |||
| BRAF V600E | Mono | 0.54 (5.2) | |||
| BRAF V600E | NKCD8 | -0.37 (3.1) | |||
| BRAF V600E | Tcell | 0.59 (10.1) | |||
| BRAF V600E | Treg | 0.75 (19.8) | |||
| BRAF V600E | TregCD8 | 0.49 (7.9) | |||
| KRAS G12V | MFm2 | -2.81 (2.8) | |||
| NRAS mutant | Bcell | -0.8 (3.7) | |||
| NRAS mutant | Tcell | -0.82 (4.7) | |||
| NRAS mutant | Treg | -0.74 (3.6) | |||
| NRAS Q61R | Bcell | -0.81 (2.2) | |||
| NRAS Q61R | NK | 1.64 (2.4) | |||
| NRAS Q61R | Tcell | -0.82 (2.8) | |||
| NRAS Q61R | Treg | -0.7 (2.2) |
Values are reported as Effect Size with associated P values in parenthesis (-log10 P). The units of effect size are change in signature score (units of standard deviation) for mutant versus wild type.