Table 7. Association of FGFR3 mutations with estimates of immune cell types across TCGA.

Variant	Signature	Bladder	Head and Neck
FGFR3 mutant	Bcell	-0.71 (5.3)
FGFR3 mutant	MFm2	-1.09 (15.7)
FGFR3 mutant	Mono	-1 (12.5)
FGFR3 mutant	Tcell	-0.51 (1.8)
FGFR3 mutant	Treg	-0.72 (6.9)
FGFR3 G382R	NK		4.61 (5)
FGFR3 S249C	MFm2	-0.86 (1.9)

Values are reported as Effect Size with associated P values in parenthesis (-log10 P). The units of effect size are change in signature score (units of standard deviation) for mutant versus wild type.