Table 2. Multivariable logistic analysis of risk factor for baseline carotid plaque in each group.
| Euthyroidisma | Subclinical hypothyroidismb | |||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age (years) | 1.083 (1.079, 1.088) | <0.001 | 1.072 (1.041, 1.104) | <0.001 |
| Female | 1.946 (1.738, 2.180) | <0.001 | 0.823 (0.390, 1.737) | 0.61 |
| Free T4 (ng/dL) | 1.094 (0.919, 1.303) | 0.311 | 0.380 (0.097, 1.486) | 0.164 |
| SBP (mm Hg) | 1.015 (1.011, 1.018) | <0.001 | 1.017 (1.002, 1.032) | 0.023 |
| DBP (mm Hg) | 0.992 (0.987, 0.996) | <0.001 | ||
| BMI (kg/m2) | 1.020 (1.006, 1.033) | 0.005 | ||
| TG (mg/dL) | 1.000 (0.999, 1.000) | 0.690 | ||
| LDL-C (mg/dL) | 1.005 (1.004, 1.006) | <0.001 | ||
| HDL-C (mg/dL) | 0.994 (0.991, 0.997) | <0.001 | ||
| ALT (U/L) | 0.998 (0.995, 1.001) | 0.283 | ||
| AST (U/L) | 1.005 (1.001, 1.009) | 0.020 | ||
| FBS (mg/dL) | 1.002 (0.999, 1.004) | 0.199 | 1.022 (1.002, 1.042) | 0.03 |
| HbA1c (%) | 1.207 (1.143, 1.274) | <0.001 | 0.719 (0.470, 1.101) | 0.129 |
| Creatinine (mg/dL) | 0.869 (0.696, 1.085) | 0.216 | 13.105 (1.782, 96.359) | 0.012 |
| CRP (mg/dL) | 1.075 (0.976, 1.185) | 0.141 | ||
| Current smoker | 1.197 (1.111, 1.290) | <0.001 | ||
| Exercise (>3/week) | 1.051 (0.979, 1.128) | 0.169 | ||
| Metabolic syndrome | 1.130 (1.034, 1.236) | 0.007 | ||
Multivariable logistic regression analysis was performed in each group. Adjusted variables in multivariable analysis were selected based on a P value < 0.1 in results from univariable analyses.
a Multivariable analysis was performed using age, female, free T4, SBP, DBP, BMI, TG, LDL-C, HDL-C, ALT, AST, FBS, HbA1c, creatinine, CRP, current smoker, exercise and metabolic syndrome which was P < 0.1 in univariable analysis in euthyroidism subjects.
b Multivariable analysis was performed using age, female, free T4, SBP, FBS, HbA1c and creatinine which was P < 0.1 in univariable analysis in subclinical hypothyroidism subjects.
Abbreviations: OR, odd ratio; CI, confidence intervals; TSH, serum thyrotropin; BMI, body mass index; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; FBS, fasting blood sugar; HbA1c, hemoglobin A1c; CRP, C-reactive protein.