Table 1.
Demographic data, fertility history, and pregnancy history for BRCA1 carriers, BRCA2 carriers, BRCA negative women, and low-risk controls
| Demographic Data | BRCA1 (n=55) | BRCA2 (n=50) | BRCA - (n=26) | Controls (n=64) |
|---|---|---|---|---|
| Age (years)* | 31.4 (5.5) | 30.9 (6.2) | 34.3 (6.7) | 30.9 (5.6)a |
| Caucasian race, n (%) | 50 (90.9%) | 48 (96.0%) | 24 (92.3%) | 57 (89.1%) |
| African American race, n (%) | 3 (5.5%) | 0 (0%) | 1 (3.8%) | 4 (6.3%) |
| Hispanic ethnicity, n (%) | 2 (3.4%) | 3 (6.0%) | 0 (0%) | 2 (3.1%) |
| Body Mass Index (kg/m2)*ϕ | 25.7 (5.3) | 23.9 (4.1) | 26.9 (7.3) | 24.3 (3.7) |
| Current smoking, n (%) | 2 (3.6%) | 4 (8.0%) | 0 (0%) | 5 (7.8%) |
| History of Smoking, n (%) | 12 (21.8%) | 14 (28.0%) | 6 (23.1%) | 15 (23.4%) |
| History of Cancer, n (%)δ | 3 (5.6%) | 1 (2.0%) | 4 (15.4%) | 1 (1.6%)a |
| Hormonal contraceptive use, n (%) | 16 (29.1%) | 13 (26.0%) | 6 (23.1%) | 20 (31.3%) |
| Progestin-secreting IUD use, n (%) | 10 (18.2%) | 7 (14.0%) | 3 (11.5%) | 7 (10.9%) |
| Regular menses, n (%) | 42 (76.4%) | 38 (76.0%) | 22 (84.6%) | 54 (84.4%) |
| Early follicular phase, n (%) | 38 (69.1%) | 37 (74.0%) | 16 (61.5%) | 49 (76.6%) |
| Graduated college, n (%) | 50 (90.9%) | 42 (84.0%) | 23 (88.5%) | 53 (84.1%) |
| Family history of BRCA mutation, n (%) | 48 (87.3%) | 44 (88.0%) | 16 (61.5%) | 0 (0%)a,b,c |
| Jewish ancestry, n (%) | 18 (32.7%) | 9 (18.0%) | 3 (11.5%) | 5 (7.8%)b |
| Fertility and Pregnancy History | ||||
| Nulligravid, n (%) | 31 (57.4%) | 31 (62.0%) | 11 (42.3%) | 45 (71.4%)a |
| Parous, n (%) | 19 (34.6%) | 14 (28.0%) | 13 (50.0%) | 13 (20.3%)a |
| Age at first birth (years)* | 30.6 (5.1) | 27.1 (5.6) | 28.6 (3.8) | 24.7 (4.7)a,b |
| Tried to conceive, n (%) | 23 (41.8%) | 20 (40.8%) | 13 (50.0%) | 13 (20.3%)a,b,c |
| History of infertility, n (%) | 12 (21.8%) | 12 (24.0%) | 1 (3.8%) | 0 (0%)b,c |
| Any infertility treatment, n (%) | 4 (7.3%) | 7 (14.0%) | 1 (3.8%) | 0 (0%)b,c |
| Prior intrauterine insemination, n (%) | 3 (5.5%) | 2 (4.0%) | 1 (3.8%) | 0 (0%) |
| Prior in vitro fertilization, n (%) | 1 (1.8%) | 2 (4.0%) | 0 (0%) | 0 (0%) |
| Mean, unadjusted AMH (ng/mL)* | 3.26 (2.83) | 2.72 (3.08) | 2.13 (2.31) | 3.20 (2.62)a |
a
p<0.05 for BRCA negative vs. controls
b
p<0.05 for BRCA1 vs. control
c
p<0.05 for BRCA2 vs. control
*
Presented as mean (standard deviation)
ϕ
Data available for 80 subjects: 18 BRCA1, 18 BRCA2, 8 BRCA-, and 36 controls
δ
Cancer diagnoses included: Breast cancer (n=4), thyroid cancer (n=2), and skin cancer (n=3).