Table 2A.

Linear regression models for Anti-Mullerian Hormone for BRCA1 carriers, BRCA2 carriers, and BRCA Negative women compared to low-risk controls. Data modeled as natural log of AMH and presented as geometric mean ratio (GMR) with 95% confidence intervals (CI).

Model	BRCA1		BRCA2		BRCA -
	GMR (95% CI)	P value	GMR (95% CI)	P value	GMR (95% CI)	P value
Age-adjusted (n=195)1	1.03 (0.73–1.44)	0.873	0.72 (0.51–1.02)	0.067	0.86 (0.55–1.33)	0.490
Fully-adjusted (n=195)2	0.99 (0.71–1.38)	0.966	0.67 (0.47–0.94)	0.021	0.84 (0.55–1.28)	0.414
Fully-adjusted, mutation verified (n=171)2	0.93 (0.65–1.35)	0.719	0.59 (0.41–0.86)	0.006	0.84 (0.54–1.30)	0.429
Fully-adjusted, excluding subjects with history of infertility (n=170) 2	0.98 (0.68–1.41)	0.893	0.66 (0.45–0.98)	0.038	0.81 (0.52–1.26)	0.346
Fully-adjusted, including only subjects with BMI available (n=80)3	0.86 (0.49–1.52)	0.607	0.51 (0.28–0.91)	0.023	0.58 (0.27–1.26)	0.165
Fully-adjusted, restricted to women < 40 years old with regular menses (n=135)4	1.00 (0.70–1.44)	0.999	0.67 (0.45–0.98)	0.037	0.58 (0.35–0.95)	0.031
Fully-adjusted, restricted to women < 40 years old with regular menses, mutation verified (n=122)4	0.93 (0.63–1.38)	0.733	0.59 (0.39–0.89)	0.012	0.58 (0.35–0.96)	0.036
Fully-adjusted, restricted to women < 40 years old with regular menses, mutation verified and BMI available (n=58)5	0.91 (0.49–1.68)	0.747	0.33 (0.17–0.63)	0.001	0.44 (0.21–0.94)	0.035

¹Adjusted for age and age²

²Adjusted for age, age², hormonal contraceptive use, African American race, and regular menses.

³Adjusted for age, age², hormonal contraceptive use, African American race, regular menses, and body mass index.

⁴Adjusted for age, age², hormonal contraceptive use, and African American race.

⁵Adjusted for age, age², hormonal contraceptive use, African American race, and body mass index.