Table 2B.
Logistic regression models for odds of low Anti-Mullerian Hormone (<1.0 ng/mL) for BRCA1 carriers, BRCA2 carriers, and BRCA negative women compared to low-risk controls. Data presented as Odds Ratio (OR) with 95% CI.
| Model | BRCA1 | BRCA2 | BRCA - | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age-adjusted (n=195)1 | 1.32 (0.48–3.61) | 0.593 | 3.26 (1.22–3.61) | 0.018 | 1.15 (0.34–3.85) | 0.826 |
| Fully-adjusted (n=195)2 | 1.46 (0.53–4.06) | 0.476 | 3.69 (1.34–10.19) | 0.012 | 1.11 (0.32–3.83) | 0.869 |
| Fully-adjusted, mutation verified (n=171)2 | 1.86 (0.64–5.46) | 0.256 | 5.28 (1.77–15.78) | 0.003 | 1.11 (0.32–3.89) | 0.864 |
| Fully-adjusted, excluding subjects with history of infertility (n=170) 2 | 1.23 (0.41–3.63) | 0.714 | 3.08 (1.01–9.36) | 0.048 | 1.21 (0.36–4.08) | 0.759 |
| Fully-adjusted, including only subjects with BMI available (n=80)3 | 1.75 (0.32–9.71) | 0.520 | 6.06 (1.11–33.1) | 0.038 | 0.33 (0.02–6.32) | 0.460 |
| Fully-adjusted, restricted to women < 40 years old with regular menses (n=135)4 | 1.59 (0.50–5.09) | 0.436 | 2.94 (0.91–9.49) | 0.072 | 1.30 (0.27–6.21) | 0.741 |
| Fully-adjusted, restricted to women < 40 years old with regular menses, mutation verified (n=122)4 | 2.12 (0.64–7.05) | 0.733 | 4.74 (1.37–16.44) | 0.014 | 1.28 (0.26–6.16) | 0.759 |
| Fully-adjusted, restricted to women < 40 years old with regular menses, mutation verified and BMI available (n=58)5 | 1.15 (0.14–9.42) | 0.894 | 11.40 (1.55–83.8) | 0.017 | 1.23 (0.08–18.42) | 0.879 |
1
Adjusted for age only
2
Adjusted for age, hormonal contraceptive use, and regular menses.
3
Adjusted for age, hormonal contraceptive use, regular menses and body mass index.
4
Adjusted for age and hormonal contraceptive use.
5
Adjusted for age, hormonal contraceptive use, and body mass index