Skip to main content
. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Calcium Bind Proteins. 2006 Oct-Dec;1(4):203–212.

Figure 4.

Figure 4

The proposed mechanism of calcium-dependent inactivation in CaV1.2. Top left figure shows the channel in the open state. Dotted lines from the EF-domain to the I-II region and to the IQ/A/C region indicate binding interactions. In the absence of calcium, these interactions must be interrupted for I-II mediated inactivation. In the presence of calcium, conformational changes allow the I-II to inactivate while preserving the I-II/EF interaction, speeding the process fivefold. Figure based on reference 28.