Table 1.

Summary of available tools and approaches to study cell division defects and/or chromosome segregation errors.

Approach		Inhibited target	Error efficiency	Initial manipulation required?	Inducible?	Prolonged mitosis required?	Trackable system?
Random	Nocodazole	Microtubules	Low	No	Yes	Yes	No
	Colcemid	Microtubules	Low	No	Yes	Yes	No
	Taxol	Microtubules	Low	No	Yes	Yes	No
	Monastral	Eg5	Low	No	Yes	Yes	No
	STLC	Eg5	Low	No	Yes	Yes	No
	GSK923295	CENP-E	Low	No	Yes	Yes	No
	Reversine	Mps1	High	No	Yes	No	No
	AZ3146	Mps1	High	No	Yes	No	No
Selective	Human artificial chromosome	HAC centromere	High	Yes	Yes	No	Yes
	Microcell-mediated chromosome transfer	None	N/A	Yes	No	No	Yes
	CENP-A replacement	Y centromere	High	Yes	Yes	No	Yes