Table 1.
Approach | Inhibited target | Error efficiency | Initial manipulation required? | Inducible? | Prolonged mitosis required? | Trackable system? | |
---|---|---|---|---|---|---|---|
Random | Nocodazole | Microtubules | Low | No | Yes | Yes | No |
Colcemid | Microtubules | Low | No | Yes | Yes | No | |
Taxol | Microtubules | Low | No | Yes | Yes | No | |
Monastral | Eg5 | Low | No | Yes | Yes | No | |
STLC | Eg5 | Low | No | Yes | Yes | No | |
GSK923295 | CENP-E | Low | No | Yes | Yes | No | |
Reversine | Mps1 | High | No | Yes | No | No | |
AZ3146 | Mps1 | High | No | Yes | No | No | |
Selective | Human artificial chromosome | HAC centromere | High | Yes | Yes | No | Yes |
Microcell-mediated chromosome transfer | None | N/A | Yes | No | No | Yes | |
CENP-A replacement | Y centromere | High | Yes | Yes | No | Yes |