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. 2017 Jul 27;12(7):e0182141. doi: 10.1371/journal.pone.0182141

Fig 5. Patients with NAFLD/NASH exhibit elevated ERRγ and fibrinogen expression in the liver.

Fig 5

(A) Left: representative immunohistochemistry results for ERRγ expression in liver tissue, as identically found in all three analysed patients with NASH. Right: serial sections of steatotic liver tissue showing colocalization of ERRγ and Fibrinogen staining. (B) Fibrinogen levels in blood of healthy controls and overweight patients. (C) qPCR analysis showing mRNA levels of hepatic fibrinogen gamma and ERRγ in liver tissue of healthy controls and patients with NAFLD. * p<0.05, ** p<0.01. (D) Proposed model for CB1 receptor–mediated induction of fibrinogen gene expression via ERRγ. Activation of hepatic CB1 receptor increases ERRγ gene expression, which in turn leads to fibrinogen expression causing hyperfibrinogenemia. GSK5182, an ERRγ inverse agonist, inhibits CB1 receptor–mediated fibrinogen gene expression.