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. 2017 Jul 17;13(7):e1006517. doi: 10.1371/journal.ppat.1006517

Fig 4. Stabilization of p53 and destabilization of p21 by C60.

Fig 4

(A) Western blot of extracts from Mutu I, LCL352, Akata EBV+, Akata EBV-, and BJAB cells treated with DMSO (D) or C60 and probed with antibody to either CAND1, p53, p53 pS15, Cul1, CDC25, ZTA, EA-D, p21, γH2AX, or β-Actin, as indicated. (B) Comparison of C60 with TPA/NaB relative to DMSO control at 24 and 48 hrs post treatment in Mutu-LCL (M-LCL) and Mutu I cells. (C) Western blot of LCL352 cells transduced with shCtrl or shCAND1_1 were probed with antibodies to CAND1, p53 S15, p53, EA-D, p21, γH2AX, or β-Actin.