Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CAND1 recycles Cullins to generate new CRLs that degrade ZTA (right red arrow). C60 alters CAND1 interaction with Cullins to prevents ubiquitin-mediated degradation of ZTA, resulting in EBV reactivation from latency. C60 works through a different arm of the pathway than proteasome inhibitor MG132 or NAE inhibitor MLN4924.
