Table 1.
Effects of PCP, DOI, WIN, and AM 411 on accuracy in the high-count trials of RD sessions
| Drug | Dose (mg/kg) | Component Discrimination challenge level | High ratio accuracy | # observations | Discrimination challenge level | High ratio accuracy | # observations |
|---|---|---|---|---|---|---|---|
| PCP | A group | B group | |||||
| 30 versus 5 | 30 versus 1 | ||||||
| Vehicle | Distract | 95.3% (±2.3) | 7 | 97.4% (±2.4) | 6 | ||
| Regular | 94.0% (±3.0) | 7 | 96.8% (±2.0) | 6 | |||
| 1 | Distract | 82.4% (±9.2) | 8 | 91.1% (±5.4) | 5 | ||
| Regular | 72.5% (±11.7) | 8 | 88.1% (±5.4) | 5 | |||
| 2 | Distract | 53.1% (±8.0)a | 4 | 36.7% (±16.7)a | 6 | ||
| Regular | 37.1% (±13.8)a | 5 | 27.5% (±9.4)a | 6 | |||
| 3 | Distract | 72.2% (±14.5)a | 3 | 48.3% (±2.6)a | 3 | ||
| Regular | 50.0% (±28.9)a | 3 | 44.4% (±8.1)a | 3 | |||
| DOI | A group | B group | |||||
| 30 versus 5 | 30 versus 1 | ||||||
| Vehicle | Distract | 90.9% (±3.0) | 7 | 97.0% (±2.9) | 4 | ||
| Regular | 95.4% (±3.0) | 7 | 94.4% (±3.5) | 4 | |||
| 0.2 | Distract | 80.8% (±7.1) | 8 | 82.3% (±6.7) | 5 | ||
| Regular | 80.2% (±8.8) | 8 | 87.4% (±5.4) | 5 | |||
| 0.4 | Distract | 54.5% (±12.8) | 7 | 55.6% (±3.0) | 3 | ||
| Regular | 66.7% (±7.9) | 7 | 64.3% (±3.2) | 3 | |||
| 0.6 | Distract | 37.5% (±21.0)a | 5 | 50.0% (±5.0) | 2 | ||
| Regular | 36.1% (±16.5)a | 5 | 33.3% (±3.3) | 2 | |||
| WIN | A group | B group | |||||
| 30 versus 5 | 30 versus 1 | ||||||
| Vehicle | Distract | 96.2% (±2.6) | 7 | 95.8% (±4.0) | 3 | ||
| Regular | 86.6% (±1.1) | 7 | 100.0% (±0) | 3 | |||
| 3.8 | Distract | 91.3% (±2.6) | 7 | 100.0% (±0) | 3 | ||
| Regular | 77.2% (±3.4) | 7 | 82.8% (±8.1) | 3 | |||
| 5.3 | Distract | 75.6% (±15.5) | 6 | 73.2% (±8.7) | 3 | ||
| Regular | 66.5% (±13.5) | 6 | 81.0% (±13.3) | 3 | |||
| 10 | Distract | 74.6% (±15.5) | 6 | 71.4% (±71)b | 2 | ||
| Regular | 67.3% (±8.2) | 6 | 42.9% (±43)b | 2 | |||
| AM | A group | B group | |||||
| 411 | 30 versus 5 | 30 versus 1 | |||||
| Vehicle | Distract | 90.6% (±3.4) | 7 | 96.3% (±2.7) | 5 | ||
| Regular | 90.4% (±3.4) | 7 | 95.3% (±3.1) | 5 | |||
| 1 | Distract | 66.7% (±14.3) | 6 | 89.6% (±5.4) | 5 | ||
| Regular | 71.7% (±14.7) | 6 | 87.1% (±9.8) | 5 | |||
| 1.8 | Distract | 89.3% (±6.7) | 5 | 80.0% (±20.1) | 5 | ||
| Regular | 80.8% (±11.2) | 5 | 90.3% (±6.7) | 5 | |||
| 3 | Distract | 66.9% (±17.4) | 7 | 62.3% (±21.5) | 4 | ||
| Regular | 50.4% (±13.6) | 7 | 63.8% (±22) | 4 | |||
| 5.3 | Distract | 85.7% (±2.8) | 2 | 65.0% (±33.3) | 4 | ||
| Regular | 78.9% (±21.3) | 2 | 62.5% (±31.2) | 4 |
Accuracy is tabulated as a percentage and reflects the total number of correct high-count trials divided by the total number of high-count trials. Data shown are means and SEM. The number of rats tested in groups A and B, respectively, is designated under observation, although accuracy scores were excluded for sessions where fewer than five trials were observed
a
Significant difference from the vehicle value assessed by Duncan’s post hoc following a GLM assay to ascertain overall significance
b
Measured trend toward differing from vehicle (p=0.06) assessed by Duncan’s post hoc following a GLM assay to ascertain overall significance