Table 3.

Risk of Atrial Fibrillation associated with PR-Interval and Components by Age, Sex, and Race

PR-interval/component*	Subgroup	HR (95%CI)†	P-value	P-interaction
Prolonged PR-interval	Age
	<54 years	1.22 (0.88, 1.69)	0.24	0.85
	≥54 years	1.23 (1.02, 1.47)	0.027
	Sex
	Female	1.43 (1.14, 1.80)	0.0021	0.033
	Male	1.02 (0.82, 1.27)	0.87
	Race
	Black	1.08 (0.82, 1.44)	0.58	0.31
	White	1.25 (1.03, 1.51)	0.025
Prolonged P-wave	Age
	<54 years	1.44 (1.03, 1.99)	0.032	0.67
	≥54 years	1.59 (1.32, 1.92)	<0.0001
	Sex
	Female	1.79 (1.39, 2.31)	<0.0001	0.056
	Male	1.34 (1.08, 1.65)	0.0074
	Race
	Black	1.67 (1.25, 2.24)	0.0006	0.52
	White	1.42 (1.17, 1.73)	0.0005
Prolonged P-wave onset to P-wave peak	Age
	<54 years	1.33 (0.92, 1.92)	0.13	0.54
	≥54 years	1.79 (1.46, 2.20)	<0.0001
	Sex
	Female	1.50 (1.13, 1.99)	0.0048	0.70
	Male	1.63 (1.29, 2.06)	<.0.0001
	Race
	Black	1.48 (1.07, 2.05)	0.018	0.45
	White	1.64 (1.32, 2.03)	<0.0001
Prolonged P-wave peak to P-wave end	Age
	<54 years	1.23 (0.87, 1.75)	0.25	0.38
	≥54 years	1.18 (0.93, 1.49)	0.17
	Sex
	Female	1.30 (0.96, 1.75)	0.090	0.42
	Male	1.13 (0.87, 1.45)	0.36
	Race
	Black	1.12 (0.73, 1.74)	0.60	0.78
	White	1.22 (0.98, 1.51)	0.078
Prolonged PR-segment	Age
	<54 years	1.27 (0.84, 1.90)	0.26	0.42
	≥54 years	1.02 (0.80, 1.29)	0.91
	Sex
	Female	1.24 (0.93, 1.65)	0.14	0.12
	Male	0.89 (0.65, 1.20)	0.44
	Race
	Black	0.88 (0.60, 1.30)	0.53	0.21
	White	1.14 (0.89, 1.46)	0.30

^*PR-interval >200 ms and PR-interval component values >95th percentile of their distribution.

^†HRs are presented for abnormal P-wave indices compared with those who had normal values. Model adjusted for age, sex, race, body mass index, heart rate, systolic blood pressure, smoking, diabetes, low-density lipoprotein cholesterol, coronary heart disease, and heart failure.

AF=atrial fibrillation; CI=confidence interval; HR=hazard ratio.