Scheme 2.
Synthesis of compound 7p, a water-soluble analog of the indole-2-carboxylic acid ester of MMB (7a). Reagents: a) dimethylamine, methanol, RT, 6 h; b) 6a, EDCI, DMAP, DCM, RT, 8 h; c) Fumaric acid, ethanol.
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