Table 3.

EC₅₀ (μM)^a values for PTL (1), MMB (3), MMB heteroaryl ester conjugates 7a–7o, and dimethylamine MMB ester conjugate 7p against M9-ENL1 AML cells

Entry	MMB Conjugate	M9-ENL1 AML Viability
		EC50 (μM)	95% Cl
1	1	5.5	[5.1–5.9]
2	7a	1.1	[0.90–1.4]
3	7b	1.8	[0.90–3.3]
4	7c	2.8	[2.5–3.2]
5	7d	3.8	[3.5–4.0]
6	7e	3.0	[2.8–3.2]
7	7f	2.5	[2.2–2.7]
8	7g	4.0	[3.9–4.1]
9	7h	2.0	[1.8–2.1]
10	7i	2.7	[2.5–3.2]
11	7j	0.7	[0.68–0.77]
12	7k	1.9	[1.9–2.8]
13	7l	7.2	[6.3–8.3]
14	7m	2.7	[2.3–3.1]
15	7n	2.1	[2.0–2.3]
16	7o	2.9	[2.7–3.2]
17	7p	2.8	[2.6–3.1]

^aEC₅₀ values below 2μM are bolded.