. Author manuscript; available in PMC: 2018 Aug 18.

Published in final edited form as: Eur J Med Chem. 2017 May 11;136:393–405. doi: 10.1016/j.ejmech.2017.05.031

Table 4.

EC₅₀ (95% CI, μM) values^a for PTL (1), and MMB heteroaryl ester conjugates 7a, 7b, and 7j against primary AML cell specimens

Com.	AML01	AML02	AML03	AML04

	EC₅₀	EC₅₀	EC₅₀	EC₅₀
1	5.2 [4.6–6.0]	6.3 [5.6–7.0]	1.9 [1.6–2.2]	13 [11–15]
7a	3.5 [3.1–4.0]	2.7 [2.6–2.8]	2.9 [2.1–3.8]	2.2 [2.0–2.5]
7b	3.0 [2.7–3.2]	3.3 [3.0–3.6]	2.2 [1.7–3.0]	3.3 [3.0–3.8]
7j	1.3 [1.2–1.5]	0.91 [0.82–1.1]	0.32[0.24–0.53]	1.0[0.83–1.4]

EC₅₀ values ≤1μM are bolded.