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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Thorac Oncol. 2017 May 6;12(8):1268–1279. doi: 10.1016/j.jtho.2017.04.017

Figure 5. Lung cancer patients have increased serum IL-17. Increase in neutrophils is associated with decreased lymphocytes.

Figure 5

A) IL-17A levels in the sera of lung cancer patients and healthy controls n=10 for patients and 9 for control group. p=0.0003. B) Expression of IL17A, G-CSF (CSF3), and IL6 in EGFR and Kras mutant lung cancer samples from the TCGA dataset EGFR n=21, Kras n=75 samples 1. Expression of IL17A, CSF3, and IL6 were calculated from Log2 values of the RNA sequencing data. p=0.049, p=0.0103, and p=0.1546 for IL17A, G-CSF and IL-6 respectively. P values were calculated using Mann-Whitney test in graph-pad prism. C) Correlations of neutrophils (CD45+ CD66b+) vs T cells (CD45+ CD3+) in freshly resected patient NSCLC samples (Kras mutant) were calculated as % of immune cells in total CD45+ cells in all samples. p value was calculated by linear regression using graph-pad prism. n=35.