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. Author manuscript; available in PMC: 2017 Sep 27.
Published in final edited form as: Oncogene. 2017 Mar 27;36(30):4277–4287. doi: 10.1038/onc.2017.61

Figure 3. Tumors implanted into LKB1endo−/− mice exhibited increased angiogenesis.

Figure 3

A, Frozen sections of 2-week LLC tumors were stained with CD31, and the vascular area in LLC tumors was quantified. Bar = 100 μm. *, P< 0.05, compared with WT (n = 6). B, LLC cells were implanted into WT or LKB1endo−/− mice. After 28 days, tumors were harvested and quantified. *, P< 0.05, compared with WT (n = 8). C, Frozen sections of 4-week LLC tumors were stained with CD31 and the vascular area was quantified. Bar = 100 μm. *, P< 0.05, compared with WT (n = 6). D, Representative Ki-67 immunohistochemical images. Bar = 50 μm. Ki-67–positive signals in LLC tumors were quantified. *, P < 0.05, compared with WT (n = 5). E, Western blot analysis of cleaved Caspase-3 level in LLC tumors (n=6). Data are mean ± SE.