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. 2017 Jul 27;7:6703. doi: 10.1038/s41598-017-06949-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The microfluidic cell retention device. (a) Cell retention by hollow fiber membranes and microfluidic cell retention device. (b) The schematic of the spiral microfluidic cell retention device. The channel size is 26 mm × 26 mm with 8 loops and its volume is 28 μL. The width is 600 μm, and outer and inner depths are 130 μm and 80 μm, respectively. 10.5 million/mL CHO cells occupied their equilibrium positions near the inner wall and went to the inner outlet. The cell-limited harvest stream flowed into the outer outlet. The two streams from outlets were collected in the tubes. The cell concentration of the harvest stream (outer outlet) had 0.3 million cells/mL with the cell retention efficiency of 97%. Scale bar, 500 μm.