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. 2017 Jul 27;7:6747. doi: 10.1038/s41598-017-06439-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic effect in AlbT3 mice after 16 weeks of high-fat diet (HFD). (A) glucose (n = 20 per group); insulin levels and HOMA-IR (n = 8 per group). (B) IPGTT and intraperitoneal insulin tolerance test (IPITT) (n = 13 per group). (C) Timp3, Adam17 and Tnf-α mRNA expression (normalized to β-actin) and (D) TIMP3, ADAM17 and TNF-α protein levels in livers of AlbT3 and wt mice. (E) ADAM17 activity in livers and TNF-α levels in serum of wt and AlbT3 (n = 7 per group). (F) Akt phosphorylation (pSer473-Akt) in liver, skeletal muscle and WAT (n = 5 per group). A representative cropped image of 3 mice per group is shown. (*p < 0.05, **p ≤ 0.02, ***p ≤ 0.005, ****p < 0.002; Student’s t test, data are means ± SEM). AUC: area under the curve.