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. 2017 Jul 27;7:6644. doi: 10.1038/s41598-017-06291-z

Figure 1.

Figure 1

Identification of the putative dominant pacemaker by Isl1 detection. (A) Histological section of sinuatrial junction of the adult Anolis equestrie, showing the left and right leaflet of the sinuatrial valve (lsav and rsav, respectively). Isl1 in myocardial nuclei is expressed (arrow heads) immediately upstream of the sinuatrial valve in a ring-like domain. (B) This cartoon indicates the sectioning plane (A-A) relative to the sinuatrial junction (SA) and whole heart. The outline of the sinus venosus is indicated in grey. (C,D) Isl1 in the adult Python regius is expressed as in Anolis. LA, left atrium; RA, right atrium; SV, sinus venosus; V, ventricle.