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. 2017 Jul 27;7:6644. doi: 10.1038/s41598-017-06291-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The sinuatrial junction of reptiles has the phenotype of the mammalian sinus node. (A,B) In the near-hatching Anolis sagrei, Isl1 was detected cranial to the sinuatrial junction (A), where the sinus node is found in mammals, at the base of the sinuatrial valve and in the most proximal part of the left sinus horn (B). (C,D) The domain of Isl1 (C) overlaps with the domain of Tbx3 (D). (E–H) The anole sinus myocardium proximal to the sinuatrial junction expresses Tbx3 and Hcn4, but not Gja5. avc, atrioventricular canal; lsav, left leaflet of the sinuatrial valve; LA, left atrium; LSH, left sinus horn; RA, right atrium; rsav, right leaflet of the sinuatrial valve; RSH, right sinus horn; sa-orifice, sinuatrial-orifice; tr, trachea.