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. 2017 Jul 28;8:150. doi: 10.1038/s41467-017-00209-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Schematic description of the end-on conversion process. On laterally attached kinetochores, outer-kinetochore associated Aurora-B kinase and BubR1-PP2A phosphatase levels are high. End-on conversion requires the reduction of outer-kinetochore associated Aurora-B activity, which potentially tips the balance in favour of BubR1-associated PP2A phosphatase allowing the gradual recruitment of Astrin-SKAP complex. Concomitantly, end-tethered kinetochores experience end-on pulling and intra-kinetochore tension, which can spatially separate centromeric Aurora-B from outer-kinetochore substrates. This progressive reduction in Aurora-B activity at the outer-kinetochore will promote further enrichment of Astrin-SKAP complex—a crucial late event in end-on conversion that is essential to maintain mature end-on attachments. Red circles mark outer and inner kinetochore associated Aurora-B, green circles mark BubR1 and blue circles mark Astrin-SKAP