Table 4.
Demographic and baseline determinants of the different groups
| Groups | Sex | Age (at Tx) | Tx (Live Donor) | Creatinine clearance MDRD | BKV− first detection* (months from Tx) | BKV Viruria cp/mL (duration - months) | BKV Viremia cp/mL (duration - months) | IL28B Genotype |
|---|---|---|---|---|---|---|---|---|
| Group 1 (BKV+/BKVAN+) | ||||||||
| 1 | F | 28 | KPT | 41 | 27 | 4.3E + 06 (P) | 2.0E + 03 (P) | C/T |
| 2 | M | 60 | DKT | 31 | 4 | 1.0E + 07 (P) | 2.6E + 04 (P) | C/T |
| 3 | M | 68 | DKT | 24 | 1 | 1.0E + 07 (P) | 4.7E + 02 (P) | C/C |
| 4 | M | 42 | KPT | 13 | 16 | 1.0E + 07 (P) | 1.0E + 06 (P) | C/C |
| 5 | M | 55 | Kidney | 14 | 2 | 1.0E + 07 | 2.0E + 02 | T/T |
| 6 | M | 65 | DKT | 16 | 4 | 5.3E + 03 (P) | 7.5E + 04 (48) | C/T |
| 7 | M | 69 | Kidney | 23 | 2 | 1.0E + 07 (P) | 3.5E + 05 (7) | C/T |
| 8 | M | 69 | Kidney | 25 | 2 | 4.0E + 05 (P) | 9.1E + 05 (P) | C/T |
| 9 | M | 48 | Kidney | 43 | 8 | NP | 1.3E + 04 (24) | T/T |
| 10 | F | 48 | Kidney | 30 | 32 | 1.0E + 07 (P) | 1.2E + 05 (P) | C/T |
| 11 | F | 64 | KPT | 56 | 3 | 6.6E + 07 (24) | 1.7E + 05 (24) | C/C |
| Group 2 (BKV+/BKVAN−) | ||||||||
| 1 | M | 56 | KPT | 138 | 24 | NP | 4.7E + 02 (12) | C/C |
| 2 | F | 67 | DKT | 25 | 16 | 1.0E + 07 (P) | 3.2E + 03 (P) | C/C |
| 3 | M | 45 | Kidney | 53 | 6 | 3.7E + 05 (P) | 3.1E + 05 (51) | C/C |
| 4 | F | 42 | Kidney | 54 | 1 | 1.6E + 04 (1) | 0 | C/C |
| 5 | M | 59 | Kidney | 41 | 23 | 5.0E + 04 (P) | 1.7E + 04 (P) | C/C |
| 6 | M | 36 | KPT | 35 | 41 | NP | 1.9E + 02 (1) | C/T |
| 7 | M | 36 | KPT | 27 | 50 | 1.2E + 08 (P) | 3.0E + 05 (P) | C/T |
| 8 | F | 34 | Kidney | 33 | 24 | 9.7E + 02 (2) | 2.2E + 02 (1) | C/C |
| 9 | M | 45 | KPT | 64 | 21 | 8.0E + 06 (36) | 2.1E + 05 | C/C |
| 10 | M | 63 | DKT | 68 | 4 | 3.21E + 04 (P) | 1.4E + 05 (20) | C/T |
| 11 | M | 56 | DKT | 48 | 3 | 1.0E + 07 (P) | 3.2E + 05 (7) | C/C |
| 12 | F | 42 | Kidney | 49 | 23 | 4.5E + 07 (P) | 5.5E + 03 (P) | C/T |
| 13 | M | 65 | Kidney | 27 | 52 | 1.0E + 03 (P) | 3.3E + 02 (5) | C/T |
| 14 | F | 41 | KPT | 53 | 54 | 8.7E + 03 | 3.5E + 01 | C/C |
| 15 | F | 36 | KPT | 58 | 41 | 8.7E + 02 | 9.2E + 01 | C/C |
| 16 | F | 40 | KPT | 102 | 54 | NP | 1.0E + 02 | C/C |
| 17 | M | 66 | Kidney | 48 | 27 | 2.5E + 04 (P) | 1.6E + 02 (24) | T/T |
| 18 | M | 54 | (Kidney) | 60 | 15 | 1.0E + 06 (P) | 3.6E + 02 (27) | C/T |
| 19 | M | 45 | (Kidney) | 66 | 3 | 5.0E + 05 (11) | 1.0E + 03 (11) | C/T |
| 20 | M | 52 | Kidney | 17 | 28 | 3.1E + 03 (P) | 1.1E + 04 (64) | C/T |
| 21 | M | 66 | DKT | 75 | 3 | 1.1E + 08 (P) | 1.9E + 03 (P) | C/T |
| 22 | M | 46 | KPT | 87 | 54 | NP | 1.E + 02 | C/C |
| Group 3 (BKV−/BKVAN−) | ||||||||
| 1 | F | 61 | Kidney | 19 | — | 0 | 0 | C/C |
| 2 | M | 31 | (Kidney) | 43 | — | 0 | 0 | C/C |
| 3 | M | 42 | (Kidney) | 29 | — | 0 | 0 | C/C |
| 4 | M | 68 | Kidney | 8 | — | 0 | 0 | C/C |
| 5 | F | 48 | Kidney | 15 | — | 0 | 0 | C/T |
| 6 | M | 40 | Kidney | 74 | — | 0 | 0 | C/T |
| 7 | F | 35 | Kidney | 13 | — | 0 | 0 | C/C |
| 8 | M | 59 | Kidney | 17 | — | 0 | 0 | C/T |
| 9 | F | 33 | (Kidney) | 31 | — | 0 | 0 | C/T |
| 10 | M | 68 | Kidney | 47 | — | 0 | 0 | C/C |
| 11 | M | 60 | Kidney | 28 | — | 0 | 0 | C/T |
| 12 | F | 38 | KPT | 94 | — | 0 | 0 | C/T |
| 13 | M | 41 | Kidney | 27 | — | 0 | 0 | C/T |
| 14 | F | 36 | KPT | 21 | — | 0 | 0 | C/C |
| 15 | M | 45 | Kidney | 78 | — | 0 | 0 | T/T |
| 16 | M | 44 | Kidney | 46 | — | 0 | 0 | C/T |
| 17 | F | 35 | Kidney | 12 | — | 0 | 0 | C/T |
Abbreviations: Crea – Serun Creatinine level in mg/dl, Tx – Transplantation, BKV – BK virus, BKVAN – BK Virus Associated Nephropathy, DKT - Double Kidney Transplantation, KPT - Kidney-Pancreas Transplant, Pos – Positive, Neg – Negative, Nb- No biopsy, ND – No Data, NP – Not Performed, P – Persistent, MDRD – Modification of Diet in Renal Disease.
*Months from transplantation to BKV-first detection – calculation was made from 2009 (introducing BKV real-time PCR quantitative assay) for patients who were transplanted before that date.