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. 2017 Jul 27;7:6645. doi: 10.1038/s41598-017-06341-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity Pathway Analysis of TBI-induced miRNA target genes in dying vs surviving hippocampal neurons. miRNA-targeted genes are disproportionately represented in three prosurvival pathways, axon guidance, ERK/MAPK, and Ephrin receptor signaling. Prosurvival miRNA-target genes that are universally downregulated in the dying neurons are upregulated in surviving neurons (dashed lines connect the same region in dying pathway images with the enlarged surviving pathway images).