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. 2017 Jul 27;7:6676. doi: 10.1038/s41598-017-06011-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hobit^pos CD56^bright liver NK cells express high levels of markers related to tissue residency. (a) Contour plots showing expression CD69 (left plot), CXCR6 (middle plot) and CD49a (right plot) compared to Hobit on CD56^bright (red) and CD56^dim (blue) NK cells in the liver. Frequency (b) and expression levels (c) of CD69, CXCR6 and CD49a comparing Hobit^pos (full symbols) to Hobit^neg (open symbols) CD56^bright NK cells from the liver. (d) Fold change (left panel) of CD69-, CXCR6- and CD49a-positive CD56^bright liver NK cells comparing Hobit^pos to Hobit^neg cells. (e) Fold increase of the MFI (right panel) of CD69, CXCR6 and CD49a on CD56^bright liver NK cells comparing Hobit^pos with Hobit^neg cells. Wilcoxon matched pair sign rank test was used to determine statistical differences in the scatter plots.