Table 1.
The parent structures of compounds 1–4 and their IC50 values.
| Compound ID | Parent structure | Compound name | IC50 for TcSpdSyn (μM) |
|---|---|---|---|
| 1 |
|
2-(2-Fluorophenyl)ethanamine | 124 |
| 2 |
|
2-[(4,6-dihydroxy-1,3,5-triazin-2-yl)amino]-4H-1,3-benzothiazin-4-one | 28 |
| 3 |
|
2-(5-Ethoxy-1-ethyl-1H-indol-3-yl)ethanamine | 113 |
| 4 |
|
4-(2-Aminoethyl)-1,2-benzenediol | 66 |
| 4MCHA |
|
trans-4-methylcyclohexylamine | 1.9 |
These IC50 values were determined from fitting curve in Supplementary Figure 3. Compound name is taken from the following Web site: http://www.chemspider.com/StructureSearch.aspx.