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. 2017 Jul 27;7:6643. doi: 10.1038/s41598-017-06910-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of FSS and antagomir-352 on the expression of IGF2R, IGF2 and Beclin1 in collateral vessels of rat hind limbs. (A) IGF2R immunostaining and qPCR. (B) IGF2 immunostaining and qPCR. (C) Beclin1 immunostaining and qPCR. Specific fluorescence in green; red fluorescence for CD31 in A and for α-SM-actin in (B and C) blue fluorescence labels nuclei. Ligature: ligature-only side; Shunt: AV-shunt side; antagomir-352: antagomir-352 treated-side; antagomir-cont: antagomir-352 control. Both shunting and antagomir-352 treatment up-regulated expression of IGF2R, IGF2 and Beclin1 (***P < 0.001, **P < 0.01, *P < 0.05, n = 5).