Table 1.

Twenty up-regulated miRNAs.

miRNA	Fold change AV-shunt vs. control	Function
rno-miR-653-3p	37.56097561	Unknown
rno-miR-3594-3p	9.31358885	Unknown
rno-miR-483-3p	8.414634146	Anti-apoptotic oncogene, cardiovascular inflammation and remodelling
rno-miR-92b-5p	8.096126255	Heart development and atrial fibrillation
rno-miR-377-5p	4.84735544	Atrial fibrillation and structural remodelling
rno-miR-341	4.764878049	Atrial fibrillation and TGF-β/Smad2/3 pathway
rno-miR-21-3p	4.637785208	Cell proliferation and invasion.
rno-miR-675-5p	4.143757751	Premature senescence of cardiac progenitor cells, G1 arrest, reduced cell proliferation, colony formation, migration and invasion
rno-miR-183-3p	3.74730108	Regulates claudin-1 expression
rno-miR-299a-5p	3.626723224	Anti-apoptotic role
rno-miR-200c-3p	3.593610443	Targets the VEGF-VEGFR2 pathway and angiogenesis
rno-miR-665	3.511737089	Negatively targets anti-apoptotic BCL2L1
rno-miR-291a-5p	3.457928187	VSMC migration
rno-miR-490-5p	2.373358	Tumour suppressor
rno-miR-1	2.505729	Suppresses cell growth
rno-miR-133b	2.192279	Inhibits cell proliferation and invasion
rno-miR-30c-1-3p	2.70761	Suppresses PXR expression
rno-miR-294	2.010496	Promotes proliferation and differentiation
rno-miR-127-5p	2.780488	A regulator of MMP-13 and suppresses cell growth
rno-miR-503	2.327383	Inhibits cell proliferation and invasion