Table 2.
Twenty down-regulated miRNAs.
| miRNA | Fold change AV-shunt vs. control | Function |
|---|---|---|
| rno-let-7f-5p | −5.200726271 | Proangiogenesis and pulmonary arterial hypertension |
| rno-miR-98-5p | −4.790951973 | Inhibits angiogenesis and regulates MMP-11 |
| rno-miR-100-5p | −4.56496786 | Neovascularization |
| rno-miR-30a | −2.712938546 | Inhibits the proliferation and migration of endothelial cells, promotes apoptosis and reduces autophagy activity |
| rno-let-7a-5p | −3.643793535 | Inhibits endothelial and vascular smooth muscle cell proliferation |
| rno-miR-26a-5p | −3.478532104 | Suppresses angiogenesis |
| rno-miR-99a-5p | −3.150019751 | Suppresses proliferation and migration |
| rno-miR-497-5p | −2.888349061 | Anti-angiogenesis and negatively regulates MMP-9 and VEGFA |
| rno-miR-352 | −2.873047456 | Regulates lysosomal-associated membrane protein 2 |
| rno-let-7d-5p | −2.854490731 | Vascular smooth muscle cell proliferation |
| rno-miR-29b-3p | −2.78013317 | Atypical coronary artery disease, abdominal aortic aneurysm suppresses angiogenesis and regulates MMP-2 and VEGF |
| rno-miR-30c-5p | −2.774625087 | Angiogenesis, vascular smooth muscle cell calcification, regulates angiogenesis and autophagy |
| rno-let-7c-5p | −2.738042055 | let-7 family and inhibits proliferation and migration |
| rno-miR-145-5p | −2.209690820 | Inhibits angiogenesis |
| rno-miR-27b | −2.373222456 | Inhibits angiogenesis and regulates VEGF-C and MMP-13 |
| rno-let-7b | −2.14686718 | Promotes angiogenesis and suppresses apoptosis and autophagy |
| rno-miR-30e | −2.15284326 | Induces apoptosis and regulates SMC proliferation and differentiation |
| rno-miR-10a-5p | −2.36103536 | Pro-angiogenic activity and regulates VEGF and VE-cadherin |
| rno-miR-181a | −2.1600044 | Inhibits angiogenesis and regulates MMP-14 |
| rno-miR-27a-3p | −2.6992738 | Regulates VE-cadherin, cell proliferation, apoptosis and MMP13 |