Table 4. Predictors of poor anticoagulation quality (TTR <60%).
| Variable | TTR ≥60% (n=379) |
TTR <60% (n=851) |
Unadjusted analysis | Adjusted analysis | |||
|---|---|---|---|---|---|---|---|
| p* | OR (95% CI)† | Model 1 OR (95% CI)† |
Model 2 OR (95% CI)† |
Model 3 OR (95% CI)† |
|||
| Age, years | 69.2±10.0 | 70.5±9.6 | 0.0275 | 1.01 (1.00–1.03) | 1.01 (0.99–1.02) | 1.01 (0.99–1.02) | 1.01 (0.99–1.03) |
| Age category for CHADS2 | 0.1209 | ||||||
| <75 years | 263 (69.4) | 552 (64.9) | Reference | ||||
| ≥75 years | 116 (30.6) | 299 (35.1) | 1.24 (0.95–1.61) | ||||
| Age category for CHA2DS2-VASc | 0.2831 | ||||||
| <65 years | 99 (26.1) | 201 (23.6) | Reference | ||||
| 65–74 years | 164 (43.3) | 351 (41.3) | 1.06 (0.78–1.43) | ||||
| ≥75 years | 116 (30.6) | 299 (35.1) | 1.28 (0.93–1.77) | ||||
| Female | 45 (38.3) | 378 (44.4) | 0.0436 | 1.31 (1.02–1.67) | 0.82 (0.56–1.22) | 0.82 (0.56–1.23) | 0.85 (0.55–1.30) |
| Height, cm | 164.0±8.4 | 162.1±8.8 | 0.0003 | 0.97 (0.96–0.99) | 0.97 (0.94–0.99) | 0.97 (0.94–0.99) | 0.97 (0.94–0.99) |
| Weight, kg | 64.3±11.1 | 62.5±11.6 | 0.0117 | 0.99 (0.98–1.00) | 1.00 (0.99–1.02) | 1.00 (0.99–1.02) | 1.00 (0.99–1.02) |
| NIHSS score | 5.29±5.3 | 6.24±6.2 | 0.0063 | 1.03 (1.01–1.05) | |||
| NIHSS score category | 0.0056 | ||||||
| <8 | 287 (76.1) | 578 (68.3) | Reference | ||||
| 8–16 | 72 (19.1) | 189 (22.3) | 1.30 (0.96–1.77) | 1.22 (0.88–1.69) | 1.22 (0.88–1.69) | 1.22 (0.88–1.69) | |
| >16 | 18 (4.8) | 79 (9.3) | 2.18 (1.28–3.71) | 2.51 (1.44–4.37) | 2.50 (1.43–4.36) | 2.50 (1.44–4.35) | |
| Creatinine level, mg/dL | 0.97±0.34 | 1.03±0.61 | 0.0367 | 1.26 (0.96–1.65) | 1.27 (0.96–1.69) | 1.27 (0.96–1.69) | 1.28 (0.96–1.71) |
| CHADS2 score | 3.28±0.93 | 3.44±0.96 | 0.0065 | 1.20 (1.06–1.37) | 1.04 (0.85–1.27) | ||
| CHA2DS2-VASc score | 4.58±1.38 | 4.82±1.42 | 0.0061 | 1.13 (1.04–1.24) | 0.98 (0.82–1.16) | ||
| Congestive heart failure | 38 (10.0) | 104 (12.2) | 0.2661 | 1.29 (0.87–1.91) | |||
| Hypertension | 251 (66.2) | 591 (69.5) | 0.2617 | 1.16 (0.90–1.51) | |||
| Diabetes mellitus | 81 (21.4) | 234 (27.5) | 0.0231 | 1.39 (1.04–1.85) | 1.42 (1.05–1.93) | 1.36 (0.93–2.01) | 1.46 (1.01–2.10) |
| Vascular disease | 67 (17.7) | 143 (16.8) | 0.7067 | 0.93 (0.67–1.27) | |||
Data are n (%) or mean±SD values except where indicated otherwise. Model 1: adjusted for age, sex, height, weight, NIHSS score category, creatinine level, and diabetes (variables with p<0.1 based on protocol), Model 2: adjusted for age, sex, height, weight, NIHSS score category, creatinine level, diabetes, and CHADS2 score, Model 3: adjusted for age, sex, height, weight, NIHSS score category, creatinine level, diabetes, and CHA2DS2-VASc score.
*p value for unadjusted analysis: for categorical variables, chi-square test or Fisher's exact test; for continuous variables, t-test or Wilcoxon rank-sum test, †By logistic regression model; modeling the probability of TTR <60%.
NIHSS: National Institutes of Health Stroke Scale, OR: odds ratio, TTR: time in therapeutic range.