Table 2.

SAR of R′ Substituent Antimalarial Activity: Aliphatic and Glycoside Groups.

Entry	Compound	R	R′	IC50 (SE) µM	IC50 (SE) µg/mL
1	6p	CH2CH(CH3)2		62 (±2.5)	31 (±1.2)
2	6q	CH2CH(CH3)2		8.4 (±0.5)	4.1 (±0.3)
3	6r	CH2CH(CH3)2		7 (±0.7)	3.5 (±0.34)
4	6s	CH2CH(CH3)2		No IC50	No IC50
5	6t	CH2CH(CH3)2		28 (±0.7)	14 (±0.3)
6	6u	CH2CH(CH3)2	H	0.7 (±0.0)	0.3 (±0.0)
7	6v	CH(CH3)CH2CH3		No IC50	No IC50
8	6w	CH(CH3)CH2CH3		15.6 (± 0.0)	11.6 (± 0.0)
9	6x	CH(CH3)CH2CH3		No IC50	No IC50
10	6y	CH(CH3)CH2CH3		No IC50	No IC50
11	6z	CH(CH3)CH2CH3	H	No IC50	No IC50
12	6a′	CH(CH3)2		No IC50	No IC50
13	6b′	CH(CH3)2		7.2 (±0.0)	3.8 (±0.0)
14	6c′	CH(CH3)2		No IC50	No IC50
15	6d′	CH(CH3)2		48.3 (±0.6)	20 (±0.29)
16	6e′	CH(CH3)2		16.7 (±21)	6.9 (±10.1)